He was born on 22 October 1937 to Greek Cypriot immigrants in Alexandria, Egypt. His parents came from the small village of Agioi Vavatsinias, in the district of Larnaca, Cyprus. Loizos moved to Athens at the age of 17 intending to study pharmacology but soon gave up his studies in order to concentrate on his musical career. He was a self-taught musician, with no formal musical arts training. His first recordings were made in 1963 but he started gaining a larger audience after 1967. By 1975 Loizos had become one of the most popular artists in Greek music.